Hexanoic Anhydride

Hexanoic Anhydride

Chemical Formula: C₁₂H₂₂O₃
Molecular Weight: 214.30 g/mol
CAS Number: 2051-49-2
Synonyms: Caproic anhydride
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Description
Technical Parameters

Physical and Chemical Properties

 

 

Appearance

Colorless to pale yellow liquid at room temperature.

Melting Point

Approximately –40°C to –41°C.

Boiling Point

Typically ranges from 244°C to 254°C (slight variation across sources).

Density

About 0.928 g/mL (at 20°C).

Solubility

Soluble in organic solvents such as ethanol and diethyl ether. It is moisture-sensitive and hydrolyzes slowly in water to form hexanoic acid.

 

Main Applications

 

Organic Synthesis Reagent

Primarily used to introduce the hexanoyl group into other molecules for chemical modification.

Polymer Modification

Reacts with hydroxyl or amino groups in polymers (e.g., chitosan) to alter hydrophobicity or mechanical properties.

Chromatographic Analysis

Used as a derivatization reagent for alcohols and amines to form esters and amides, improving detection and separation.

 

Safety and Storage

 

Hazards

Corrosive; may cause severe skin burns and eye damage (GHS05). Also may cause skin sensitization (H317).

Storage

Due to its moisture sensitivity, it should be stored sealed in a cool, dry place under inert gas protection. Typical shelf life is 2–3 years.

 

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